1H-Indole, 6-fluoro-3-[(1E)-2-(2H-tetrazol-5-yl)ethenyl]-
(E)-3-(2-(1H-TETRAZOL-5-YL)VINYL)-6-FLUORO-1H-INDOLE
CAS: 1316695-35-8
Molecular Formula: C11H8FN5
1H-Indole, 6-fluoro-3-[(1E)-2-(2H-tetrazol-5-yl)ethenyl]- - Names and Identifiers
1H-Indole, 6-fluoro-3-[(1E)-2-(2H-tetrazol-5-yl)ethenyl]- - Physico-chemical Properties
| Molecular Formula | C11H8FN5 |
| Molar Mass | 229.21 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| In vitro study | LM10 (Ki = 5.6 μm) had high selectivity and no inhibitory effect on IDO. |
| In vivo study | LM10 had higher plasma concentrations and oral bioavailability after administration in mice. After oral administration of LM10 at 160 mg/kg/day to mice, the drug plasma concentration was between 20-40 μg/mL(87-175 μm). Systemic Treatment of immunized mice with LM10 at 160 (mg/kg)/day inhibited the growth of P815 tumor cells expressing TDO. LM10 treated mice showed no signs of toxicity |
1H-Indole, 6-fluoro-3-[(1E)-2-(2H-tetrazol-5-yl)ethenyl]- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.363 ml | 21.814 ml | 43.628 ml |
| 5 mM | 0.873 ml | 4.363 ml | 8.726 ml |
| 10 mM | 0.436 ml | 2.181 ml | 4.363 ml |
| 5 mM | 0.087 ml | 0.436 ml | 0.873 ml |
Last Update：2024-01-02 23:10:35
1H-Indole, 6-fluoro-3-[(1E)-2-(2H-tetrazol-5-yl)ethenyl]- - Reference Information
| Biological activity | LM10 is a selective tryptophan dioxygenase (TDO) inhibitor. The IC50 for inhibiting human and mouse TDO is 0.62 μM and 2 μM respectively. |
| target | TargetValue mTDO (in P815B cells) 2 μM |
| Target | Value |
| mTDO (in P815B cells) | 2 μM |
| In vitro study | LM10 (Ki = 5.6 μM) has high selectivity and has no inhibitory effect on IDO. |
| in vivo study | LM10 has high plasma concentration and oral bioavailability after administration in mice. After oral administration of 160 mg/kg/day LM10 in mice, the drug plasma concentration was between 20-40 μg/mL(87-175 μM). Systemic treatment of immunized mice with 160 (mg/kg)/day LM10 was able to inhibit the growth of P815 tumor cells expressing TDO. LM10 treated mice have no obvious toxic symptoms |
Last Update：2024-04-09 02:00:03
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Spot supply
Product Name: (E)-3-(2-(1H-TETRAZOL-5-YL)VINYL)-6-FLUORO-1H-INDOLE Visit Supplier Webpage Request for quotationCAS: 1316695-35-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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